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Study on cytotoxicity of contraceptive materials of scrotiform intrauterine device

Zhong Xingming,Wei Xiangcai,Zhu Guoping,Li Yanqiu,Wu Yuanyuan,Li Zhicai,Guo Jianhua,Zeng Xingrong

Strategic Study of CAE 2015, Volume 17, Issue 6,   Pages 8-12

Abstract:

Objective: To evaluate the cytotoxicity of contraceptive materials of scrotiform Intrauterine DeviceMethod: Make a cytotoxicity experiment with the additional liquid silicone rubber newly developed (formulasolution group, positive control solution group, 100% ,50%,25% material extract group’s cell cytotoxicity

Keywords： intrauterind device     silicone rubber material     cytotoxicity     animal experiment ；mouse    

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Head-to-tail cyclization of a heptapeptide eliminates its cytotoxicity and significantly increases its

Shuai Ma, Huan Zhang, Xiaoyan Dong, Linling Yu, Jie Zheng, Yan Sun

Frontiers of Chemical Science and Engineering 2018, Volume 12, Issue 2,   Pages 283-295 doi: 10.1007/s11705-017-1687-2

Abstract: promising inhibitory capability on A fibrillation, but is prone to self-assembling and displays high cytotoxicitydifferent self-assembly behavior from LK7, and has higher stability against proteolysis than LK7 and little cytotoxicitycLK7 to stabilize the secondary structure of A and potently inhibit its nucleation, fibrillation and cytotoxicityat extensive concentration range, whereas LK7 could only moderately inhibit A fibrillation and cytotoxicity

Keywords： Alzheimer’s disease     amyloid β-protein     cyclic peptide     inhibition     protein aggregation    

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Identification of important precursors and theoretical toxicity evaluation of byproducts driving cytotoxicity

Qian-Yuan Wu, Yi-Jun Yan, Yao Lu, Ye Du, Zi-Fan Liang, Hong-Ying Hu

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 2, doi: 10.1007/s11783-019-1204-6

Abstract: showed the highest toxicity index during chlorination • Dichloroacetonitrile might be a driving DBP for cytotoxicitydetermine the main DBPs driving toxicity using a theoretical toxicity evaluation of contributions to the cytotoxicity

Keywords： Chlorination     Dichloroacetonitrile     Aspartic acid     Asparagine     Toxicity index    

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Control strategies for disinfection byproducts by ion exchange resin, nanofiltration and their sequential combination

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 10, doi: 10.1007/s11783-023-1725-x

Abstract:

● Effects of AER adsorption and NF on DBP precursors, DBPs, and TOX were examined.

Keywords： Disinfection byproducts     Control     Anion exchange resin     Nanofiltration     Cytotoxicity    

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Response of bioaerosol cells to photocatalytic inactivation with ZnO and TiO impregnated onto Perlite and Poraver carriers

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 3, doi: 10.1007/s11783-020-1335-9

Abstract:

•ZnO/Perlite inactivated 72% of bioaerosols in continuous gas phase.

Keywords： Immobilized catalysts     Continuous flow     Photocatalysis     Bioaerosols     Cytotoxicity     Inactivation mechanism    

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Engineered Biomimetic Platelet Membrane-Coated Nanoparticles Block Staphylococcus aureus Cytotoxicity Article

Jwa-Kyung Kim, Satoshi Uchiyama, Hua Gong, Alexandra Stream, Liangfang Zhang, Victor Nizet

Engineering 2021, Volume 7, Issue 8,   Pages 1149-1156 doi: 10.1016/j.eng.2020.09.013

Abstract:

Staphylococcus (S.) aureus is a leading human pathogen capable of producing severe invasive infections such as bacteremia, sepsis, and endocarditis with high morbidity and mortality, exacerbated by the increasingly widespread antibiotic resistance exemplified by methicillin-resistant strains (MRSA). S. aureus pathogenesis is fueled by the secretion of toxins—such as the membrane-damaging pore-forming atoxin,
which have diverse cellular targets including the epithelium, endothelium, leukocytes, and platelets. Here, we examine the use of human platelet membrane-coated nanoparticles (PNPs) as a biomimetic decoy strategy to neutralize S. aureus toxins and preserve host cell defense functions. The PNPs blocked platelet damage induced by S. aureus secreted toxins, thereby supporting platelet activation and bactericidal
activity. Likewise, the PNPs blocked macrophage damage induced by S. aureus secreted toxins, thus supporting macrophage oxidative burst, nitric oxide production, and bactericidal activity, and diminishing MRSA-induced neutrophil extracellular trap release. In a mouse model of MRSA systemic infection, PNP administration reduced bacterial counts in the blood and protected against mortality. Taken together, the results from the present work provide a proof of principle of the therapeutic benefit of PNPs in toxin neutralization, cytoprotection, and increased host resistance to invasive S. aureus infection.

Keywords： Nanoparticle     Nanosponge     Platelet     Staphylococcus aureus     Bacterial toxins     Sepsis    

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Title Author Date Type Operation

Study on cytotoxicity of contraceptive materials of scrotiform intrauterine device

Zhong Xingming,Wei Xiangcai,Zhu Guoping,Li Yanqiu,Wu Yuanyuan,Li Zhicai,Guo Jianhua,Zeng Xingrong

Journal Article

Head-to-tail cyclization of a heptapeptide eliminates its cytotoxicity and significantly increases its

Shuai Ma, Huan Zhang, Xiaoyan Dong, Linling Yu, Jie Zheng, Yan Sun

Journal Article

Identification of important precursors and theoretical toxicity evaluation of byproducts driving cytotoxicity

Qian-Yuan Wu, Yi-Jun Yan, Yao Lu, Ye Du, Zi-Fan Liang, Hong-Ying Hu

Journal Article

Control strategies for disinfection byproducts by ion exchange resin, nanofiltration and their sequential combination

Journal Article

Response of bioaerosol cells to photocatalytic inactivation with ZnO and TiO impregnated onto Perlite and Poraver carriers

Journal Article

Engineered Biomimetic Platelet Membrane-Coated Nanoparticles Block Staphylococcus aureus Cytotoxicity

Jwa-Kyung Kim, Satoshi Uchiyama, Hua Gong, Alexandra Stream, Liangfang Zhang, Victor Nizet

Journal Article